The pivotal role of carbonic anhydrase in malaria infection
Identifieur interne : 002722 ( Main/Exploration ); précédent : 002721; suivant : 002723The pivotal role of carbonic anhydrase in malaria infection
Auteurs : Kyaw Kyaw Sein [États-Unis] ; M. Aikawa [États-Unis]Source :
- Medical Hypotheses [ 0306-9877 ] ; 1998.
English descriptors
- Teeft :
- Acetazolamide, Anhydrase, Antimalarial, Antimalarial activity, Carbonic, Carbonic anhydrase, Carbonic anhydrase inhibitors, Deoxycholate, Electron microscopy, Erythrocyte, Falciparum, Falciparum malaria, Inhibitor, Intraerythrocytic, Intraerythrocytic malaria parasites, Isoenzyme, Malaria, Malaria infection, Malaria parasites, Medical hypotheses, Negative controls, Parasite, Parasitemia, Plasma membrane, Plasmodium, Plasmodium falciparum, Potassium iodide, Prbc, Reaction product, Sodium deoxycholate, Tetraethylthiuram disulfide.
Abstract
Abstract: Carbon dioxide (CO2) is essential for the growth of intraerythrocytic malaria parasites to synthesize pyrimidine through CO2 fixation and to regulate intracellular pH. CO2 transport across the plasma membrane of erythrocytes is facilitated by carbonic anhydrase (CA). With the use of electron microscopy and CA-specific Hansson's stain, CA is found also in all the intraerythrocytic stages of Plasmodium falciparum. When CA inhibitors, including acetazolamide, potassium iodide, and sodium deoxycholate, were added to continuous culture of P. falciparum, they, particularly sodium deoxycholate, produced a marked reduction in parasitemia. These results explain the biochemical basis of some of the clinical conditions associated with malaria and strongly suggest that CA inhibitors have potential as a new class of antimalarials.
Url:
DOI: 10.1016/S0306-9877(98)90172-4
Affiliations:
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Aikawa</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Hypotheses</title><title level="j" type="abbrev">YMEHY</title><idno type="ISSN">0306-9877</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">50</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="19">19</biblScope><biblScope unit="page" to="23">23</biblScope></imprint><idno type="ISSN">0306-9877</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-9877</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetazolamide</term><term>Anhydrase</term><term>Antimalarial</term><term>Antimalarial activity</term><term>Carbonic</term><term>Carbonic anhydrase</term><term>Carbonic anhydrase inhibitors</term><term>Deoxycholate</term><term>Electron microscopy</term><term>Erythrocyte</term><term>Falciparum</term><term>Falciparum malaria</term><term>Inhibitor</term><term>Intraerythrocytic</term><term>Intraerythrocytic malaria parasites</term><term>Isoenzyme</term><term>Malaria</term><term>Malaria infection</term><term>Malaria parasites</term><term>Medical hypotheses</term><term>Negative controls</term><term>Parasite</term><term>Parasitemia</term><term>Plasma membrane</term><term>Plasmodium</term><term>Plasmodium falciparum</term><term>Potassium iodide</term><term>Prbc</term><term>Reaction product</term><term>Sodium deoxycholate</term><term>Tetraethylthiuram disulfide</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Carbon dioxide (CO2) is essential for the growth of intraerythrocytic malaria parasites to synthesize pyrimidine through CO2 fixation and to regulate intracellular pH. CO2 transport across the plasma membrane of erythrocytes is facilitated by carbonic anhydrase (CA). With the use of electron microscopy and CA-specific Hansson's stain, CA is found also in all the intraerythrocytic stages of Plasmodium falciparum. When CA inhibitors, including acetazolamide, potassium iodide, and sodium deoxycholate, were added to continuous culture of P. falciparum, they, particularly sodium deoxycholate, produced a marked reduction in parasitemia. These results explain the biochemical basis of some of the clinical conditions associated with malaria and strongly suggest that CA inhibitors have potential as a new class of antimalarials.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Kyaw Sein, Kyaw" sort="Kyaw Sein, Kyaw" uniqKey="Kyaw Sein K" first="Kyaw" last="Kyaw Sein">Kyaw Kyaw Sein</name></region><name sortKey="Aikawa, M" sort="Aikawa, M" uniqKey="Aikawa M" first="M." last="Aikawa">M. Aikawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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